Mushrooms for Depression? Psilocybin is Showing Promising Results
People are becoming increasingly interested in classic psychedelics as potential interventions to treat a range of mental health conditions, including depression, anxiety, PTSD, end-of-life distress, and substance use disorders.
Psilocybin is a classic psychedelic that is showing promising results in producing positive therapeutic outcomes in a controlled setting.
Benjamin Lewis, MD, director of the Ketamine-Assisted Psychotherapy (KAP) Clinic at 亚洲自慰视频 of Utah 亚洲自慰视频鈥檚 Park City Behavioral 亚洲自慰视频 Clinic and an assistant professor of psychiatry at the Huntsman Mental 亚洲自慰视频 Institute, provides information about the potential intervention.
What is psilocybin?
Psilocybin is a psychoactive compound found in certain mushroom species鈥攁lso known as magic mushrooms. It acts on a specific subtype of serotonin receptor in the brain, which can result in alterations to mood, cognition, and perception. It is possible that these changes in consciousness may enable therapeutic growth.
鈥淧eople taking psilocybin often have experiences of significant insight into aspects of their lives, their relationships, and their sources of meaning鈥攚ho they are as a person and how that has shaped their lives,鈥 Lewis says. 鈥淭hat kind of experience is an important component of treating people with depression.鈥
Psilocybin is currently a Schedule I drug and not approved by the Food and Drug Administration for clinical use.
What does the research show?
The study and research of psilocybin began in the 1940s as a psychedelic medicine to treat various psychiatric conditions such as depression, substance use disorders, and alcohol use disorders. All research and clinical use of psilocybin was shut down in the 1970s after it was declared a Schedule I drug, ultimately becoming illegal.
鈥淭here are misconceptions of psychedelics, what they do or don鈥檛 do, and what the risks are,鈥 Lewis says. One of these misconceptions is the potential for abuse of psychedelic drugs. 鈥淐lassic psychedelics like psilocybin or LSD don鈥檛 really have abuse potential in the same fashion as other drugs like alcohol, nicotine, cocaine, and opioids,鈥 Lewis says.
It wasn鈥檛 until recently鈥攊n the last ten years鈥攖hat has looked into psilocybin and other psychedelics as potential mental health treatments. A showed that psychedelic treatment with psilocybin relieved major depressive disorder symptoms for patients for up to a month.
鈥淭here鈥檚 a lot of promise based on early studies, but those studies to date have been pretty small and limited in certain regards,鈥 Lewis says.
have looked at psilocybin as treatment for major depressive disorder and for treatment-resistant depression. While the studies are promising, Lewis says these studies are small, have limitations, and involved participants that are extensively screened and monitored through the process.
, data to date have shown promising results in treatment of:
- Major depressive disorder
- Treatment resistant depression
- Alcohol use disorder
- Anxiety at end of life, or existential distress
- Tobacco use disorder
- OCD
鈥淭here鈥檚 a lot of potential for conditions that are otherwise very difficult to treat and for which we have limited tools to address,鈥 Lewis says.
What are the side effects?
Side effects of psilocybin can be mild or intense. Mild symptoms include:
- Headache
- Nausea
- Changes in body temperature
- Elevation of heart rate and blood pressure
Psilocybin can also cause a range of psychological reactions that may be difficult or challenging for some people. These symptoms include:
- Anxiety
- Paranoia
- Disorientation
Patients who have a personal or family history of psychosis may also be at increased risk for experiencing a prolonged episode of psychosis. Those with a history of manic episodes may also be at increased risk.
How would psilocybin therapy work?
In clinical studies, administering psilocybin involves an intense psychotherapeutic preparation before taking the substance. This involves being supported during an eight-hour session with two therapists who are present the entire time. Following this session, the therapists and patient would engage in integration sessions that explore how to translate those experiences to a patient鈥檚 life.
鈥淚t鈥檚 not just taking a pill or substance to treat symptoms,鈥 Lewis says. 鈥淚t鈥檚 about the therapeutic approach, the intentions behind it, and the support that you have in doing so in a therapeutic way.鈥
Lewis points out he wouldn鈥檛 recommend psilocybin to patients at this time due to legal issues, lack of data, and the need for ongoing research.
Why psychedelics?
Approximately 30% of people treated with standard antidepressants don鈥檛 achieve remission. Psychedelics like psilocybin could be another option for those who are suffering.
鈥淎s someone who鈥檚 investing my career in terms of pursuing and investigating the therapeutic potentials of these compounds, there鈥檚 a lot of promise here,鈥 Lewis says.
While psilocybin could be a new treatment option for mental health in the future, Lewis advocates for more research and data. 鈥淲hile there are many people that are suffering that we would love to help as quickly as possible, it鈥檚 important to do that carefully and not put people at risk,鈥 he says.
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